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Sphingomonas paucimobilis: An Uncommon Cause of Bacteremia—A Case Report
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Keywords

Sphingomonas
Bacteremia
Sepsis
Blood Culture
Hospital-Acquired Infection
Opportunistic Infections

Categories

Abstract

Introduction: Sphingomonas paucimobilis is a non-fermenting Gram-negative bacillus considered a low-virulence opportunistic pathogen. Although infections caused by this microorganism are uncommon, the number of reported cases has increased in recent years, particularly among patients with comorbidities, immunosuppression, or exposure to invasive procedures. Bacteremia is its most common clinical manifestation, and the diagnosis is primarily established through microbiological isolation from blood cultures, which enables targeted antimicrobial therapy based on the organism's susceptibility profile. Case presentation: We report the case of an 88-year-old woman with right-sided colon cancer and multiple comorbidities who developed abdominal septic shock following ileostomy during hospitalization. Blood cultures yielded Sphingomonas paucimobilis, confirming the diagnosis and guiding antimicrobial treatment, with subsequent favorable clinical outcome. Conclusions: This case highlights the importance of considering S. paucimobilis in the differential diagnosis of bacteremia in hospitalized patients with predisposing factors and underscores the essential role of microbiological isolation in establishing a timely diagnosis and initiating appropriate targeted antimicrobial therapy.

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References

El Beaino M, Fares J, Malek A, Hachem R. Sphingomonas paucimobilis-related bone and soft-tissue infections: A systematic review. International Journal of Infectious Diseases. 2018 Dec 1;77:68–73. doi:10.1016/J.IJID.2018.09.021 PubMed PMID: 30267938.

Ryan MP, Adley CC. Sphingomonas paucimobilis: a persistent Gram-negative nosocomial infectious organism. Journal of Hospital Infection. 2010 Jul;75(3):153–7. doi:10.1016/j.jhin.2010.03.007

Laupland KB, Paterson DL, Stewart AG, Edwards F, Harris PNA. Sphingomonas paucimobilis bloodstream infection is a predominantly community-onset disease with significant lethality. International Journal of Infectious Diseases. 2022 Jun;119:172–7. doi:10.1016/j.ijid.2022.03.060

Johnson RC, Deming C, Conlan S, Zellmer CJ, Michelin A V., Lee-Lin S, et al. Investigation of a Cluster of Sphingomonas koreensis Infections. New England Journal of Medicine. 2018 Dec 27;379(26):2529–39. doi:10.1056/NEJMoa1803238

Lin JN, Lai CH, Chen YH, Lin HL, Huang CK, Chen WF, et al. Sphingomonas paucimobilis Bacteremia in Humans: 16 Case Reports and a Literature Review. Journal of Microbiology, Immunology and Infection. 2010 Feb 1;43(1):35–42. doi:10.1016/S1684-1182(10)60005-9 PubMed PMID: 20434121.

Tito E, Ahmad A, Gongolli J, Issack W, Johnson A. textit{Sphingomonas paucimobilis} Bacteremia in a Patient With Retropharyngeal Abscess. Cureus. 2022 May 27. doi:10.7759/cureus.25407

Toh HS, Tay HT, Kuar WK, Weng TC, Tang HJ, Tan CK. Risk factors associated with Sphingomonas paucimobilis infection. Journal of Microbiology, Immunology and Infection. 2011 Aug 1;44(4):289–95. doi:10.1016/J.JMII.2010.08.007 PubMed PMID: 21524965.

Royal College of Physicians. National Early Warning Score (NEWS) 2: Standardising the assessment of acute-illness severity in the NHS. In: Updated report of a working party. London: RCP; 2017.

Inada-Kim M. NEWS2 and improving outcomes from sepsis. Clin Med (Lond). 2022 Nov;22(6):514–7. doi:10.7861/clinmed.2022-0450 PubMed PMID: 36427883.

Holmes B, Owen RJ, Evans A, Malnich H, Willcox WR. Pseudomonas paucimobilis, a New Species Isolated from Human Clinical Specimens, the Hospital Environment, and Other Sources. Int J Syst Bacteriol. 1977 Apr 1;27(2):133–46. doi:10.1099/00207713-27-2-133

Yabuuchi E, Yano I, Oyaizu H, Hashimoto Y, Ezaki T, Yamamoto H. Proposals of phingomonas paucimobilis gen. nov. and comb. nov., Sphingomonas parapaucimobilis sp. nov., Sphingomonas yanoikuyae sp. nov., Sphingomonas adhaesiva sp. nov., Sphingomonas capsulata comb. nov., and Two Genospecies of the Genus Sphingomonas. Microbiol Immunol. 1990;34(2):99–119. doi:10.1111/j.1348-0421.1990.tb00996.x PubMed PMID: 2111872.

Takeuchi M, Hamana K, Hiraishi A. Proposal of the genus Sphingomonas sensu stricto and three new genera, Sphingobium, Novosphingobium and Sphingopyxis, on the basis of phylogenetic and chemotaxonomic analyses. Int J Syst Evol Microbiol. 2001 Jul;51(Pt 4):1405–17. doi:10.1099/00207713-51-4-1405 PubMed PMID: 11491340.

Takeuchi M, Kawai F, Shimada Y, Yokota A. Taxonomic Study of Polyethylene Glycol-Utilizing Bacteria: Emended Description of the Genus Sphingomonas and New Descriptions of Sphingomonas macrogoltabidus sp. nov., Sphingomonas sanguis sp. nov. and Sphingomonas terrae sp. nov. Syst Appl Microbiol. 1993 Jul;16(2):227–38. doi:10.1016/S0723-2020(11)80473-X

Lemaitre D, Elaichouni A, Hundhausen M, Claeys G, Vanhaesebrouck P, Vaneechoutte M, et al. Tracheal colonization with Sphingomonas paucimobilis in mechanically ventilated neonates due to contaminated ventilator temperature probes. Journal of Hospital Infection. 1996 Mar;32(3):199–206. doi:10.1016/S0195-6701(96)90146-2

Maragakis LL, Chaiwarith R, Srinivasan A, Torriani FJ, Avdic E, Lee A, et al. Sphingomonas paucimobilis bloodstream infections associated with contaminated intravenous fentanyl. Emerg Infect Dis. 2009 Jan;15(1):12–8. doi:10.3201/eid1501.081054 PubMed PMID: 19116043.

Alkhatib B, Veytsman E, Klumpp L, Hayes E. Sphingomonas paucimobilis Septic Shock in an Immunocompetent Patient. Cureus. 2022 Jul 10. doi:10.7759/cureus.26720

Kawasaki S, Moriguchi R, Sekiya K, Nakai T, Ono E, Kume K, et al. The cell envelope structure of the lipopolysaccharide-lacking gram-negative bacterium Sphingomonas paucimobilis. J Bacteriol. 1994 Jan;176(2):284–90. doi:10.1128/jb.176.2.284-290.1994

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Copyright (c) 2026 Ivan Zuluaga De Leon, Gillian Martínez Guerrero, Valeria Arbelaez Lamdrid, Daniel Lukowiecki González, Emmanuel Amado Alarza, Giannina Silva Gomez

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